Hydrochloric Acid → 5-(Chloromethyl)-2-hydroxybenzaldehyde

HRID 865939노트

반응식

HRID 865939 반응식
[CH:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[Cl:10][CH2:11]C1C=CC=C(C=1)C=O.C=O.Cl>>[Cl:10][CH2:11][C:7]1[CH:6]=[CH:5][C:3]([OH:4])=[C:2]([CH:8]=1)[CH:1]=[O:9]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 6998SalicylaldehydeHCID 223953313-(Chloromethyl)benzaldehyde

생성물 1

HCID 3352915-(Chloromethyl)-2-hydroxybenzaldehyde

실험 절차

The salicylaldehyde is convened to the 5-chloromethylbenzaldehyde by combining the aldehyde with aqueous formaldehyde (37%) and concentrated hydrochloric acid, at a reduced temperature in the range of -10° to +10° C. or thereabouts. Gaseous HCl is then bubbled through the solution to saturate with HCl after which the solution is stirred for a period sufficient to effect the reaction at a reduced temperature, one which is about that of the temperature at which the reactants were combined initially. The product, the 5-(chloromethyl)-2-hydroxybenzaldehyde, should be formed as a white precipitate which can be recovered by conventional means.

후처리

  1. customin the range of -10° to +10° C.
  2. customGaseous HCl is then bubbled through the solution
  3. concentrationto saturate with HCl after which the solution
  4. customthe reaction at a reduced temperature, one which

출처 및 근거

ORD 기록
ord-7b2ae60820514fec831f7a77ccc9ca35
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569677

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