Water → 2-(1-Benzylpyrrolidin-3-yl)acetonitrile
반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:15]#[N:16].[Na+].O>CS(C)=O>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:15]#[N:16])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.
후처리
- extractionthe mixture was extracted three times with ethyl acetate
- washThe combined organic layer was washed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-56818a6d757b4766865fa51ce27de994
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723444
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