Tetrahydrofuran → 3-Chloro-4-methoxybenzoyl chloride

HRID 866059

반응식

HRID 866059 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5](O)=[O:6].O1CCCC1.C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([Cl:21])=[O:6]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 1699823-Chloro-p-anisic acid

생성물 1

HCID 47692993-Chloro-4-methoxybenzoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A stirred solution of 0.22 gram (0.0012 mole) of 3-chloro-4-methoxybenzoic acid in a small amount of tetrahydrofuran and chloroform was cooled to 0° C., and 0.12 mL (0.0014 mole) of oxalyl chloride was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature, where it was stirred for about 3.5 hours. After this time the reaction mixture was concentrated under reduced pressure, yielding 3-chloro-4-methoxybenzoyl chloride, which was dissolved in a small amount of tetrahydrofuran for later use.

후처리

  1. additionUpon completion of addition
  2. concentrationAfter this time the reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ef7b2c9f6f784ede8ceb8024279c9555
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569664

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