Dichloromethane → 1-Bromo-4-(tert-butoxy)benzene

HRID 866236노트

반응식

HRID 866236 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10](=[CH2:12])[CH3:11].C(Cl)Cl.FC(F)(F)S(O)(=O)=O>C(N(CC)CC)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]([CH3:12])([CH3:11])[CH3:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 78084-BromophenolHCID 8255IsobutyleneHCID 62406Trifluoromethanesulfonic acid

생성물 1

HCID 27639591-Bromo-4-(tert-butoxy)benzene

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
-78 °C

실험 절차

4-Bromophenol (57.8 mmoles, 10.0 g) was added to a -30° C. solution of isobutylene (40 ml) and methylene chloride (50 ml) and then cooled to -78° C. Trifluoromethanesulfonic acid (4 mmoles, 0.35 ml) was added. The mixture was held at -78° C. for 4 hours and then allowed to warm to room temperature. Triethylamine (0.5 ml) was added; the solvent was removed. The residue was chromatographed over silica gel eluted with 1% ethyl acetate in hexane to yield 12.4 g. (MS)

후처리

  1. temperatureto warm to room temperature
  2. customthe solvent was removed
  3. customThe residue was chromatographed over silica gel
  4. washeluted with 1% ethyl acetate in hexane
  5. customto yield 12.4 g

출처 및 근거

ORD 기록
ord-03a62de067f54584a2602563e03d275e
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05569768

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