Acetonitrile → [2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-thiophen-3-yl-methylamine

HRID 8663

반응식

HRID 8663 반응식
Br[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[O:13][N:12]=2)[CH:8]=[CH:9][CH:10]=1.C(=O)([O-])[O-].[K+].[K+].[S:25]1[CH:29]=[CH:28][C:27]([NH:30][CH3:31])=[CH:26]1.C(#N)C>O>[O:13]1[C:14]2[CH:18]=[CH:17][S:16][C:15]=2[C:11]([C:7]2[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=2)[O:4][CH2:3][CH2:2][N:30]([C:27]2[CH:28]=[CH:29][S:25][CH:26]=2)[CH3:31])=[N:12]1

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 642344N-methylthiophen-3-amineHCID 219835823-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

생성물 1

HCID 69652881[2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-thiophen-3-yl-methylamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, thiophen-3-yl-methylamine (prepared according to Synthetic Metals, 26 (1988)153–168) and acetonitrile essentially as described above in example 18, except that water (0.40 mL) is added to the reaction mixture before heating. Purity by LC/MS (APCI)=100%, [M+H]+=357.

후처리

  1. additionis added to the reaction mixture
  2. temperaturebefore heating

출처 및 근거

ORD 기록
ord-9c632d1f03ef4ea1ad693653be4afc16
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091199B1

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