Ethanol → 4-(Benzyloxy)benzoic acid

HRID 866389

반응식

HRID 866389 반응식
N[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3].C([OH:20])C>[OH-].[Na+]>[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([OH:20])=[O:3]

참가 물질

4

반응물 2

HCID 702EthanolHCID 27264314-Benzyloxybenzamide

생성물 1

HCID 738804-(Benzyloxy)benzoic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 4-aminocarbonylphenoxy phenyl methane (10g) in ethanol (100ml) and sodium hydroxide (100ml., 10N) was heated under reflux with vigorous stirring for 24hrs. The reaction mixture was cooled, the precipitated sodium salt was filtered off washed with a little water then converted to 4-carboxyphenoxy phenyl methane by boiling under reflux with concentrated hydrochloric acid (100ml) for 6hr. Dilution of the cooled mixture and extraction with ether yielded 4-carboxyphenoxy phenyl methane, m.p. 188°.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitated sodium salt was filtered off
  5. washwashed with a little water
  6. temperatureunder reflux with concentrated hydrochloric acid (100ml) for 6hr
  7. extractionDilution of the cooled mixture and extraction with ether

출처 및 근거

ORD 기록
ord-628d7530e92b4426b5db4ef6ae9a0596
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04098816

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