Nicotinic Acid → 2,4-Bis(nicotinamido)-6-phenyl-s-triazine

HRID 866407

반응식

HRID 866407 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([C:7]2[N:8]=[C:9]([NH2:14])[N:10]=[C:11]([NH2:13])[N:12]=2)=[CH:5][CH:6]=1.[C:15]([OH:23])(=O)[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.C(=O)([O-])[O:25][CH2:26][CH2:27]Cl>N1C=CC=CC=1>[C:26]([NH:13][C:11]1[N:10]=[C:9]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)[N:8]=[C:7]([C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)[N:12]=1)(=[O:25])[C:27]1[CH:3]=[CH:4][CH:7]=[N:8][CH:9]=1

참가 물질

5

반응물 3

HCID 938Nicotinic AcidHCID 7064BenzoguanamineHCID 22631361Chloroethyl carbonate

생성물 1

HCID 203210352,4-Bis(nicotinamido)-6-phenyl-s-triazine수율 64.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
60 °C

실험 절차

1.9 g of benzoguanamine and 2.6 g of nicotinic acid are dissolved in 50 ml of pyridine and mixed with 2.2 g of chloroethyl carbonate. After heating the mixture at 60° C with agitation for 3 hours, it is processed as described in Example 4 to yield 1.3 g of 2,4-bis(nicotinamido)-6-phenyl-s-triazine [dinicotinoylbenzoguanamine].

출처 및 근거

ORD 기록
ord-0822b237088c43928d4831dd80ae9313
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04098892

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