Acetate → 4-t-Butylazo-4-methoxypentyl chloroformate

HRID 866742노트

반응식

HRID 866742 반응식
[C:1]1([OH:7])C=CC=CC=1.[OH-].[K+].[C:10]([O:13][CH2:14][CH2:15][CH2:16][C:17]([N:20]=[N:21][C:22]([CH3:25])([CH3:24])[CH3:23])(Cl)[CH3:18])(=[O:12])C.C([O-])(=O)C.C[O-].[Cl:32]C([O-])=O.C(Cl)(Cl)=O>CCCCC.N1C=CC=CC=1.CO>[Cl:32][C:10]([O:13][CH2:14][CH2:15][CH2:16][C:17]([N:20]=[N:21][C:22]([CH3:25])([CH3:24])[CH3:23])([O:7][CH3:1])[CH3:18])=[O:12]

참가 물질

11

반응물 7

HCID 175AcetateHCID 996PhenolHCID 6371PhosgeneHCID 14797Potassium HydroxideHCID 3826051MethoxideHCID 21226386Carbonochloridate2회HCID 233459014-t-Butylazo-4-chloropentyl acetate

생성물 1

HCID 203182464-t-Butylazo-4-methoxypentyl chloroformate

시약·촉매·용매 3

HCID 887Methanol용매HCID 1049Pyridine용매HCID 8003Pentane용매2회

실험 절차

This compound was prepared in the same manner as the 4-phenoxy derivative described in Example XXIX except that phenol was not added to the methanolic solution of KOH before the 4-t-butylazo-4-chloropentyl acetate was added in step C. The acetate was saponified to the alcohol by addition of excess base to the methanol after the reaction of the chloro compound and the methoxide was complete. The alcohol was then converted to the chloroformate by adding a pentane solution of the alcohol and pyridine to a pentane solution of phosgene as in step D of Example XXIX. The infrared spectrum confirmed that the alcohol was converted to the chloroformate.

후처리

  1. additionwas added in step C

출처 및 근거

ORD 기록
ord-0536140b539f4f48ab2927583dd906c5
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101522

반응 노트

불러오는 중…