Hydrazine hydrate (1:1) → 2-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochloride

HRID 866853노트

반응식

HRID 866853 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH2:13][N:14]3C(=O)C4=CC=CC=C4C3=O)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[ClH:1].[NH2:14][CH2:13][C:11]1[O:12][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:9][N:10]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 22762753HCID 22762753, 화합물

생성물 1

HCID 30492642-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochloride수율 154.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 3.4 g of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide and 0.55 g of 100% hydrazine hydrate in 50 ml of ethanol was heated at reflux for one hour. At the end of this period, the formed precipitate was filtered off, and the filtrate was evaporated to dryness in vacuo. The residue was shaken with 2N HCl - chloroform and the 2N HCl - layer was evaporated to dryness under vacuo. The residue was recrystallized from ethanol to give 1.9 g (78 percent) of 2-aminomethyl-5-(4-chlorophenyl) oxazole hydrochloride, M.P. 200° C (decomposition).

후처리

  1. temperatureat reflux for one hour
  2. filtrationAt the end of this period, the formed precipitate was filtered off
  3. customthe filtrate was evaporated to dryness in vacuo
  4. customthe 2N HCl - layer was evaporated to dryness under vacuo
  5. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-e9312d285a2d4482a7353beb8ea8e34e
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101660

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