Pyrrolidine → 1-(4-(Pyrrolidin-1-ylsulfonyl)phenyl)ethanone

반응식

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]([C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1)(=[O:8])[CH3:7]>>[C:6]([C:9]1[CH:10]=[CH:11][C:12]([S:15]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:17])=[O:16])=[CH:13][CH:14]=1)(=[O:8])[CH3:7]

참가 물질

반응물 2

HCID 31268Pyrrolidine

HCID 2664184-Acetylbenzenesulfonyl chloride

생성물 1

HCID 7876721-(4-(Pyrrolidin-1-ylsulfonyl)phenyl)ethanone

실험 절차

A solution of 500 ml. of 50% aqueous pyrrolidine is treated in portions with 30.0 g. of 4-acetylbenzenesulfonyl chloride and the solution is stirred at room temperature for 1 hour. The resulting mixture is cooled to 0°-5° C. and the precipitated 1-(4-acetylbenzenesulfonyl)pyrrolidine is collected by filtration, washed with water and dried; m.p. 138°-139° C. after crystallizations from aqueous methanol and from 2-propanol.

후처리

temperatureThe resulting mixture is cooled to 0°-5° C.
filtrationthe precipitated 1-(4-acetylbenzenesulfonyl)pyrrolidine is collected by filtration
washwashed with water
customdried
customm.p. 138°-139° C. after crystallizations from aqueous methanol

출처 및 근거

ORD 기록: ord-82a381e053ea4e448ea044ada0add055
출처 데이터셋: uspto-grants-1978_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04101661

반응 노트

불러오는 중…