Bromobenzene → HCID 13363395, 화합물

HRID 867003노트

반응식

HRID 867003 반응식
[C:1]([N:4]1[CH2:12][CH2:11][CH:7]([C:8](Cl)=[O:9])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[Br:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)CCl>[C:1]([N:4]1[CH2:12][CH2:11][CH:7]([C:8](=[O:9])[C:21]2[CH:22]=[CH:23][C:18]([Br:17])=[CH:19][CH:20]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 7961BromobenzeneHCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 13363395HCID 13363395, 화합물

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

32.0 g of 1-acetylisonipecotoyl chloride, Example 1(b) are added portionwise to a stirred mixture of 45.3 g of aluminum chloride, 28.3 g of bromobenzene and 120 ml of ethylene dichloride. The solution is stirred overnight, poured onto ice, the organic phase is collected, and the aqueous layer is extracted with chloroform. The organic solutions are combined, dried, and the solvent is removed under reduced pressure to give a yellow oil which crystallizes to a soft solid. The solid is triturated with ether, collected and dried to give 1-acetyl-4-(4-bromobenzoyl)piperidine.

후처리

  1. additionpoured onto ice
  2. customthe organic phase is collected
  3. extractionthe aqueous layer is extracted with chloroform
  4. customdried
  5. customthe solvent is removed under reduced pressure
  6. customto give a yellow oil which
  7. customcrystallizes to a soft solid
  8. customThe solid is triturated with ether
  9. customcollected
  10. customdried

출처 및 근거

ORD 기록
ord-409255d15f8b408fa08b756a4133c85f
출처 데이터셋
uspto-grants-1978_07
특허 번호
US04101663

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