Piperidine → HCID 178431711, 화합물

반응식

C1CCNCC1.CC1(C)OC(=O)C(Oc2ccc(Br)cn2)=C1c1ccc(S(C)(=O)=O)cc1>CS(C)=O.Cc1cccc(C)c1NC(=O)C(=O)O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CC1(C)OC(=O)C(Oc2ccc(N3CCCCC3)cn2)=C1c1ccc(S(C)(=O)=O)cc1

참가 물질

반응 조건

온도: 80 °C

후처리

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

출처 및 근거

ORD 기록: ord-99b7071ffced43b894b9fac46551019d
출처 데이터셋: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
원본 링크: 출처 보기

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참가 물질

반응물 2

HCID 8082Piperidine

HCID 99328283-((5-Bromopyridin-2-yl)oxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

생성물 1

HCID 178431711HCID 178431711, 화합물수율 23%

시약·촉매·용매 4

HCID 62657Potassium Phosphate, Tribasic시약

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매

HCID 149878692-(2,6-Dimethylphenylamino)-2-oxoacetic acid촉매

HCID 679Dimethyl Sulfoxide용매2회

반응 조건

온도: 80 °C

후처리

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

출처 및 근거

ORD 기록: ord-99b7071ffced43b894b9fac46551019d
출처 데이터셋: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
원본 링크: 출처 보기

반응 노트

불러오는 중…