Dimethylformamide → Cephalexin ethanol

HRID 867605

반응식

HRID 867605 반응식
[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].CN(C=O)C>C(O)C>[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].[CH2:7]([OH:8])[CH3:6]

참가 물질

4

반응물 2

HCID 6228DimethylformamideHCID 27447Cephalexin

생성물 1

HCID 67601003Cephalexin ethanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A slurry of 47.4 g of cephalexin bis-DMF solvate in 600 ml of 3A ethanol (K.F=0.03%) was stirred at room temperature and seeded with a few milligrams of a product from an earlier like preparation. After stirring the mixture 5 hours at room temperature, the ethanol in the mixture was evaporated until the total weight of the resulting slurry was 230 g. Filtration provided a crystalline cephalexin ethanol solvate. Air drying the product overnight, provided 35.1 g of crystalline desolvated cephalexin ethanolate.

후처리

  1. customearlier like preparation
  2. customthe ethanol in the mixture was evaporated until the total weight of the resulting slurry
  3. filtrationFiltration

출처 및 근거

ORD 기록
ord-dfcfa13629f24651a61be0a0ae541ddf
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775751

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