Ammonium Acetate → tert-Butyl ((2S,3S)-2-methyl-4-oxoazetidin-3-yl)carbamate
반응식
[C:1]([O:5][C:6]([NH:8][C@H:9]1[C@H:12]([CH3:13])[N:11](O)[C:10]1=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(=O)C.[NH4+]>CO.[Cl-].[Na+].[Cl-].[Cl-].[Cl-].[Ti+3]>[C:1]([O:5][C:6]([NH:8][C@H:9]1[C@H:12]([CH3:13])[NH:11][C:10]1=[O:15])=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
6
실험 절차
A solution of 4.98 of (3S-trans)-3-t-butoxycarbonylamino-1-hydroxy-4-methylazetidinone in 200 ml of methanol is treated with 132 ml of 4.5M ammonium acetate and then 66 ml of 1.5M titanium trichloride and stirred for 4.5 hours. The aqueous solution is diluted with an equal volume of 8% sodium chloride and extracted with ethyl acetate to give 3.48 g of crude product. Recrystallization from ether-hexane yields 3.3 g of the title compound.
후처리
- extractionextracted with ethyl acetate
- customto give 3.48 g of crude product
- customRecrystallization from ether-hexane
출처 및 근거
- ORD 기록
- ord-73b3ea52cda147bb886fa1ce3731902e
- 출처 데이터셋
- uspto-grants-1988_10
- 특허 번호
- US04775670
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