2-Chlorobenzoic Acid → Methyl 2-chlorobenzoate

HRID 867794

반응식

HRID 867794 반응식
[N+](=[CH2:3])=[N-].[Cl:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]>CCOCC>[Cl:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([O:9][CH3:3])=[O:8]

참가 물질

4

반응물 2

HCID 83742-Chlorobenzoic AcidHCID 9550Diazomethane

생성물 1

HCID 11895Methyl 2-chlorobenzoate수율 72.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

An excess solution of diazomethane in ether was added to an ice-cooled and stirred solution of o-chlorobenzoic acid (7.6 g, 48.6 mmol) in 50 ml of ether. After concentration, the residue was distilled under reduced pressure to give a colorless transparent oil of methyl o-chlorobenzoate (6.0 g, 35.2 mmol, yield 72.4%, b.p. 92°-93° C./7 mmHg), which was assigned the structure by the following data:

후처리

  1. temperaturecooled
  2. concentrationAfter concentration
  3. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-3266c0d51b2249708da94ad3e0457107
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775692

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