Sodium Hydroxide → HCID 14306132, 화합물
반응식
B(Br)(Br)Br.C[O:6][CH2:7][C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1.[OH-].[Na+]>ClCCl>[OH:6][CH2:7][C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1참가 물질
5
실험 절차
Boron tribromide (6.1 ml) was added dropwise to a stirred solution of 2-methoxymethyl-4-piperidinopyrimidine (3.35 g) in dichloromethane (60 ml) at 0°-5° under nitrogen. After a further 30 minutes the mixture was poured onto ice, the pH raised to 13 (NaOH) and extracted with chloroform. The combined extracts were dried (K2CO3) and the volume reduced. Ether was added to give 2-hydroxymethyl-4-piperidino-pyrimidine (2.78 g) as a crystalline solid, m.p. 92°-3°.
후처리
- additionAfter a further 30 minutes the mixture was poured onto ice
- extractionextracted with chloroform
- dry with materialThe combined extracts were dried (K2CO3)
- additionEther was added
출처 및 근거
- ORD 기록
- ord-01776aac310f4150985e9f039c00c48d
- 출처 데이터셋
- uspto-grants-1988_10
- 특허 번호
- US04777172
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