Water → 4-(Dimethylaminomethyl)-2-thiophenemethanol

HRID 867920노트

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HRID 867920 반응식
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[C:5]([C:8]([N:10]([CH3:12])[CH3:11])=O)[CH:4]=1.[H-].[Al+3].[H-].[H-].O>O1CCCC1.Cl>[CH3:12][N:10]([CH2:8][C:5]1[CH:4]=[C:3]([CH2:2][OH:1])[S:7][CH:6]=1)[CH3:11]

참가 물질

6

반응물 3

HCID 962WaterHCID 212890685-(Hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamideHCID 21584524Aluminiumhydride

생성물 1

HCID 129265384-(Dimethylaminomethyl)-2-thiophenemethanol

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 5-(hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamide (1.7 g) in dry tetrahydrofuran (150 ml) was treated with a 0.5M solution of aluminium hydride in tetrahydrofuran (26 ml). After 2 h at room temperature, water (5 ml) was cautiously added and the mixture was filtered through diatomaceous earth. The filtrate was evaporated to leave an oily residue, which was dissolved in 2M hydrochloric acid (20 ml). The aqueous solution was washed with diethyl ether, basified with 5M sodium hydroxide and extracted with ethyl acetate.

후처리

  1. filtrationthe mixture was filtered through diatomaceous earth
  2. customThe filtrate was evaporated
  3. customto leave an oily residue, which
  4. washThe aqueous solution was washed with diethyl ether
  5. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-83da7cd5e98f4b96a1597a8bf33d8a48
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04777179

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