Water → 2-[5-(4-Bromobutyl)-3-methyl-2-thienyl]-1,3-dioxolane
반응식
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[O:11][CH2:10][CH2:9][O:8]1.C([Li])CCC.[Br:17][CH2:18][CH2:19][CH2:20][CH2:21]Br.O>O1CCCC1.CCCCCC>[Br:17][CH2:18][CH2:19][CH2:20][CH2:21][C:5]1[S:4][C:3]([CH:7]2[O:11][CH2:10][CH2:9][O:8]2)=[C:2]([CH3:1])[CH:6]=1참가 물질
7
실험 절차
A solution of 2-(3-methyl-2-thienyl)-1,3-dioxolane (12.3 g) in dry tetrahydrofuran (150 ml) was treated with a solution of n-butyl lithium in hexane (1.6M, 50 ml) at -60°, under nitrogen. After 1 h, 1,4-dibromobutane (17.3 g) was added and the mixture was stirred at -50° for 3 h and at room temperature for 18 h. Water (75 ml) was added and the mixture extracted with ether. The organic extract was distilled to give the title compound as a light brown oil (15.1 g) b.p. 250°/0.15 mm.
후처리
- extractionthe mixture extracted with ether
- extractionThe organic extract
- distillationwas distilled
출처 및 근거
- ORD 기록
- ord-62c86ba913394a188e1014e5cb6d6e07
- 출처 데이터셋
- uspto-grants-1988_10
- 특허 번호
- US04777179
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