2-Amino-2-methyl-1-propanol → 2-(5-Bromoindan-2-yl)-4,4-dimethyloxazoline

HRID 868012노트

반응식

HRID 868012 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([C:11]([OH:13])=O)[CH2:5]2.[NH2:14][C:15]([CH3:19])([CH3:18])[CH2:16]O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([C:11]1[O:13][CH2:16][C:15]([CH3:19])([CH3:18])[N:14]=1)[CH2:5]2

참가 물질

4

반응물 2

HCID 118072-Amino-2-methyl-1-propanolHCID 219861245-bromo-2,3-dihydro-1H-indene-2-carboxylic acid

생성물 1

HCID 212895082-(5-Bromoindan-2-yl)-4,4-dimethyloxazoline수율 63%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

3.9 g of 5-bromo-2-indancarboxylic acid and 2 g of 2-amino-2-methyl-1-propanol were added to 100 ml of xylene. The mixture was heated under reflux for 24 hours while removing the water produced. The reaction mixture was concentrated in vacuo and 20 ml of water was added to the residue. The mixture was extracted with chloroform. The extract was washed with water, dried and then concentrated in vacuo. The residue was purified by silica gel column chromatography to give 3 g of 2-(5-bromoindan-2-yl)-4,4-dimethyloxazoline as an oil.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. customwhile removing the water
  4. customproduced
  5. concentrationThe reaction mixture was concentrated in vacuo and 20 ml of water
  6. additionwas added to the residue
  7. extractionThe mixture was extracted with chloroform
  8. washThe extract was washed with water
  9. customdried
  10. concentrationconcentrated in vacuo
  11. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-f60566a10b14404e8ddf99df88790e93
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04777257

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