Hydrochloric Acid → 3'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid

HRID 868473

반응식

HRID 868473 반응식
[Cl:1]N(Cl)S(C1C=CC(C)=CC=1)(=O)=O.Cl.[CH2:15]([O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>C(O)(=O)C>[Cl:1][C:25]1[CH:26]=[C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)[CH:28]=[CH:29][C:24]=1[O:23][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 68056Dichloramine-T2회HCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

생성물 1

HCID 147941813'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid수율 128.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

실험 절차

N,N-dichloro-p-toluenesulfonamide (hereinafter abbreviated to "dichloramine T") (7.5 g, 0.032 mol) was dissolved in acetic acid (100 ml), followed by adding to the solution, hydrochloric acid (0.4 ml), dropwise adding to the acetic acid solution of dichloramine T, a solution of 4'-octyloxy-4-biphenycarboxylic acid (20 g, 0.063 mol) dissolved in acetic acid (100 ml), refluxing the mixture, allowing it to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3'-chloro-4'-octyloxy-4-biphenylcarboxylic acid (14.8 g) (C-Sc 146° C., Sc 'N' 224° C. and N'-I 232° C.).

후처리

  1. temperaturerefluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

출처 및 근거

ORD 기록
ord-ecd78c79eb6c4881be2212cea45e9e26
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780242

연결된 노트

불러오는 중…