Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

HRID 868476

반응식

HRID 868476 반응식
ClNCl.[ClH:4].[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1>C(O)(=O)C>[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[C:14]([Cl:4])[CH:15]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 76939ChlorimideHCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

생성물 1

HCID 230416823-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

On the other hand, dichloroamine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).

후처리

  1. temperatureby refluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

출처 및 근거

ORD 기록
ord-d758b38bf38540e5843d0f8742dd452f
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780242

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