Hydrochloric Acid → HCID 86729195, 화합물

HRID 868824노트

반응식

HRID 868824 반응식
Cl.[C:2]([C:4]1[CH:24]=[C:23]([B:25]2[O:29][C:28]([CH3:31])([CH3:30])[C:27]([CH3:33])([CH3:32])[O:26]2)[CH:22]=[CH:21][C:5]=1[O:6][CH2:7][CH:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)#[N:3]>O1CCOCC1>[NH:11]1[CH2:12][CH2:13][CH:8]([CH2:7][O:6][C:5]2[CH:21]=[CH:22][C:23]([B:25]3[O:29][C:28]([CH3:31])([CH3:30])[C:27]([CH3:33])([CH3:32])[O:26]3)=[CH:24][C:4]=2[C:2]#[N:3])[CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86729196tert-Butyl 4-((2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)piperidine-1-carboxylate

생성물 1

HCID 86729195HCID 86729195, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

HCl in dioxane (50 ml) is added to a solution of tert-butyl 4-[2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylate (6.0 g, 0.0135 mol) in 1,4-dioxane (50 ml), and the mixture is stirred at room temperature for 16 h. The mixture is evaporated in a rotary evaporator and employed in the next step without purification.

후처리

  1. customThe mixture is evaporated in a rotary evaporator
  2. customemployed in the next step without purification

출처 및 근거

ORD 기록
ord-cdcdf2c040c641299e5b5348b8b03a78
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969335B2

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