Dimethylamine → HCID 2762435, 화합물

HRID 868838노트

반응식

HRID 868838 반응식
[CH3:1][NH:2][CH3:3].[CH2:4]=O.[CH3:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2.[OH-].[Na+]>C(O)(=O)C>[CH3:1][N:2]([CH3:4])[CH2:3][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[CH3:6])[NH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 674DimethylamineHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 852824-Methylindole

생성물 1

HCID 2762435HCID 2762435, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a chilled solution of dimethyl amine (30 mL, 40% in water, 120 mmol) and formalin (13 mL, 37% in water, 84 mmol) in glacial acetic acid (30 mL) is added 4-methyl indole (21 g, 165 mmol) at 0° C. The reaction is warmed to room temperature and stirred for 3 hours. The reaction mixture is brought to pH 12 by addition of 50% NaOH and ice, and the product extracted with methylene chloride. The organic layers are dried over Na2SO4 filtered and evaporated in vacuo to give the title compound that is used without further purification (33 g, 162 mmol, 98%) LC/MS (M++1): 205.7.

후처리

  1. extractionthe product extracted with methylene chloride
  2. dry with materialThe organic layers are dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-5e9430295ee14861a44a981cdbca0c98
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969348B2

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