Methyl iodide → HCID 86665673, 화합물

HRID 868839노트

반응식

HRID 868839 반응식
[CH3:1][N:2]([CH3:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[NH:6][CH:5]=1.[CH3:15][I:16]>C(#N)C>[I-:16].[CH3:1][N+:2]([CH3:15])([CH3:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[NH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 2762435HCID 2762435, 화합물

생성물 1

HCID 86665673HCID 86665673, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

Dimethyl-(4-methyl-1H-indol-3-ylmethyl)-amine (20 g, 98 mmol) is suspended in acetonitrile, and warmed to completely dissolve the material. The reaction is cooled to room temperature and then methyl iodide (9.1 mL, 147 mmol) is added dropwise to the reaction. The reaction is covered with foil and then stirred at room temperature overnight. The reaction is then filtered and the filtrate evaporate in vacuo to give an oil that is taken up in acetonitrile. The white solid is then triturated with acetonitrile and ether, and combined with the original solid to give the title compound that is used without further purification (30 g, 87 mmol, 88%) LC/MS (M++1): 347.

후처리

  1. temperaturewarmed
  2. dissolutionto completely dissolve the material
  3. filtrationThe reaction is then filtered
  4. customthe filtrate evaporate in vacuo
  5. customto give an oil that
  6. customThe white solid is then triturated with acetonitrile and ether

출처 및 근거

ORD 기록
ord-506eb8760e4b4118a2a54488280a975a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969348B2

반응 노트

불러오는 중…