N-bromobutanimide → 3-(Bromomethyl)isoquinolin-1(2H)-one

HRID 868906노트

반응식

HRID 868906 반응식
[CH3:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C=CC(C2C=CC(C3OC(C4C=CC=CC=4)=CN=3)=CC=2)=CC=1.[Br:36]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.CCOC(C)=O>[Br:36][CH2:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

6

반응물 3

HCID 67184N-bromobutanimideHCID 967282-(Biphenyl-4-yl)-5-phenyloxazoleHCID 32444773-Methyl-1,2-dihydroisoquinolin-1-one

생성물 1

HCID 700972123-(Bromomethyl)isoquinolin-1(2H)-one

시약·촉매·용매 2

HCID 5943Carbon Tetrachloride용매HCID 8857Ethyl Acetate용매

실험 절차

To a refluxing solution of 3-methylisoquinolin-1(2H)-one (1.7 g, 10.69 mmol) and 2-(4-biphenyl)-5-phenyloxazole (120 mg) in CCl4 (30 mL) was added N-bromosuccinimide (1.9 g, 10.7 mmol) in portions. The reaction mixture was stirred at reflux for 2 h. After cooling to room temperature, the reaction mixture was diluted with EtOAc, filtered and concentrated to give the crude product, which was used for the next step without further purification. LC-MS: m/z 238 (M+H+).

후처리

  1. temperatureat reflux for 2 h
  2. filtrationfiltered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ea588e2b03f5477e8066257f1a425e14
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969349B2

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