Hydrochloric Acid → 3-Bromo-4-chloro-5-fluoropyridine hydrochloride

HRID 869132노트

반응식

HRID 869132 반응식
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8].Cl>CCCCC>[ClH:8].[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 709772193-Bromo-4-chloro-5-fluoropyridine

생성물 1

HCID 867209403-Bromo-4-chloro-5-fluoropyridine hydrochloride수율 120.6%

시약·촉매·용매 1

HCID 8003Pentane용매

실험 절차

To a solution of 3-bromo-4-chloro-5-fluoro-pyridine (7.56 g, 32.18 mmol) in pentane (100 mL) was added hydrogen chloride (2M in ether) (17.7 mL of 2 M, 35.4 mmol). An off-white precipitate formed instantly. The mixture was stirred for 5 minutes then the solid was collected by filtration, washed with pentane and dried by suction to afford the desired product as an off-white solid (4.79 g, 60%). 1H NMR (DMSO-d6) δ 8.77 (s, 1H), 8.75 (s, 1H).

후처리

  1. customAn off-white precipitate formed instantly
  2. filtrationthe solid was collected by filtration
  3. washwashed with pentane
  4. customdried by suction

출처 및 근거

ORD 기록
ord-339a121c319b4b67a885b0d985b7ce6a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969360B2

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