Benzaldehyde → HCID 86722234, 화합물

HRID 869386노트

반응식

HRID 869386 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+].O>CO>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH:2]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 962WaterHCID 14798Sodium HydroxideHCID 86722235HCID 86722235, 화합물

생성물 1

HCID 86722234HCID 86722234, 화합물수율 92.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
45 °C

실험 절차

A mixture of 7G (1.5 g, 6.26 mmol), benzaldehyde (0.863 g, 8.14 mmol, 1.3 eq) and NaOH (1.0 g, 25.04 mmol, 4 eq) in MeOH (20 mL) was stirred at 45° C. for 24 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (20 mL) The yellow solids precipitated out were collected by filtration and dried to give product 8A (1.9 g, 92.6% yield).

후처리

  1. customthe reaction
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customprecipitated out
  4. filtrationwere collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-bfb088da04e847ed8265e7dfa61e942b
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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