Water → HCID 86722239, 화합물

HRID 869390노트

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HRID 869390 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][CH:22]=[C:23]([CH:25]=O)[N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].O>CO>[NH2:9][C:8]1[C:7]2[C:10]([Cl:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:25][C:23]1[N:24]=[C:20]([CH:17]([CH3:19])[CH3:18])[S:21][CH:22]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 27631922-(Propan-2-yl)-1,3-thiazole-4-carbaldehydeHCID 86722235HCID 86722235, 화합물

생성물 1

HCID 86722239HCID 86722239, 화합물수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
45 °C

실험 절차

A mixture of 7G (6.4 g, 26.7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (4.8 g, 30.92 mmol, 1.16 eq) and NaOH (4.27 g, 106.8 mmol, 4 eq) in MeOH (200 mL) was stirred at 45° C. for 24 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The yellow precipitates were collected by filtration and dried to give product 10A (9.96 g, 98.9% yield).

후처리

  1. customthe reaction
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customyellow precipitates
  4. filtrationwere collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-8ee97524d0b845ea82e203b6675dca9d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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