Water → HCID 86722240, 화합물

HRID 869391노트

반응식

HRID 869391 반응식
[NH2:1][C:2]1[C:6]2[C:7]([Cl:13])=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14](=[O:25])[CH:15]=[CH:16][C:17]1[N:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[S:20][CH:21]=1.O>CC(O)=O.OP(O)(O)=O>[Cl:13][C:7]1[C:6]2[C:2]3[NH:1][CH:16]([C:17]4[N:18]=[C:19]([CH:22]([CH3:23])[CH3:24])[S:20][CH:21]=4)[CH2:15][C:14](=[O:25])[C:3]=3[O:4][C:5]=2[CH:10]=[CH:9][C:8]=1[O:11][CH3:12]

참가 물질

5

반응물 2

HCID 962WaterHCID 86722239HCID 86722239, 화합물

생성물 1

HCID 86722240HCID 86722240, 화합물수율 108.4%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 1004Phosphoric Acid용매

실험 절차

10A (9.96 g, 26.43 mmol) was dissolved in AcOH (50 mL) and H3PO4 (50 mL). The solution was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The brown precipitates were collected by filtration and dried to give product 10B (10.8 g), which was used for the next step directly.

후처리

  1. temperatureThe solution was refluxed for 2 hours
  2. customthe reaction
  3. custombrown precipitates
  4. filtrationwere collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-be5b8a68658446a68a3c0d5d799e4af6
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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