Phosphorus oxychloride → HCID 86722242, 화합물

HRID 869393노트

반응식

HRID 869393 반응식
O[C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[S:11][CH:12]=2)[N:5]=[C:4]2[C:16]3[C:22]([Cl:23])=[C:21]([O:24][CH3:25])[CH:20]=[CH:19][C:17]=3[O:18][C:3]=12.O=P(Cl)(Cl)[Cl:28]>>[Cl:28][C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[S:11][CH:12]=2)[N:5]=[C:4]2[C:16]3[C:22]([Cl:23])=[C:21]([O:24][CH3:25])[CH:20]=[CH:19][C:17]=3[O:18][C:3]=12

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178488262HCID 178488262, 화합물

생성물 1

HCID 86722242HCID 86722242, 화합물

실험 절차

The crude 10C (8.75 g, 23.34 mmol) was added to POCl3 (200 mL) The mixture was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, POCl3 was evaporated under reduced pressure. The residue was poured into crushed ice under stirring. The yellow solids were collected by filtration and purified by flash chromatography to give product M10 (0.66 g).

후처리

  1. temperaturewas refluxed for 2 hours
  2. customthe reaction
  3. customPOCl3 was evaporated under reduced pressure
  4. additionThe residue was poured
  5. custominto crushed ice
  6. filtrationThe yellow solids were collected by filtration
  7. custompurified by flash chromatography
  8. customto give product M10 (0.66 g)

출처 및 근거

ORD 기록
ord-a8a8e91967864ef4b21bc3073a0eac08
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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