Hydrochloric Acid → HCID 86722249, 화합물

HRID 869404노트

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HRID 869404 반응식
[Br:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10]C(C)=O)[CH:5]=[CH:4][C:3]=1[O:14][C:15]([CH3:17])=[O:16].CO.C([O-])([O-])=O.[K+].[K+].Cl>ClCCl>[C:15]([O:14][C:3]1[CH:4]=[CH:5][C:6]([OH:10])=[C:7]([C:8]#[N:9])[C:2]=1[Br:1])(=[O:16])[CH3:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 86722248HCID 86722248, 화합물

생성물 1

HCID 86722249HCID 86722249, 화합물수율 62.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

12C (15 g, 0.05 mol) was added to MeOH (52 ml) and dichloromethane (52 mL). To the mixture was added K2CO3 (7 g, 0.05 mol) in batches at room temperature. The reaction mixture was stirred overnight at room temperture, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with dichloromethane, dried over anhydrous Na2SO4 and concentrated to give 12D (8 g, 62.1% yield).

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-079f798c7ac44463a7e558471894e8f8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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