Hydrochloric Acid → HCID 86722251, 화합물

HRID 869406노트

반응식

HRID 869406 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14]C(C)=O)=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].Cl>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 86722250HCID 86722250, 화합물

생성물 1

HCID 86722251HCID 86722251, 화합물수율 98.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a mixture of 12E (6.8 g, 0.021 mol) in MeOH (40 mL) and water (20 mL) was added K2CO3 (4.5 g, 0.032 mol) in batches at room temperature. The reaction mixture was stirred at room temperature overnight, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with ethyl acetate, dried and concentrated to give 12F (5.6 g, 95.1% yield).

후처리

  1. extractionextracted with ethyl acetate
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-70fdf9670d164dcb92cb3c74ae0e0846
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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