Water → HCID 86722252, 화합물

HRID 869407노트

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HRID 869407 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([Br:15])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[F-].[Cs+].[CH3:18]I.O>C1COCC1>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:18])=[C:10]([Br:15])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 25953Cesium fluorideHCID 86722251HCID 86722251, 화합물

생성물 1

HCID 86722252HCID 86722252, 화합물수율 42.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture of 12F (5.6 g, 0.020 mol) and CsF (9.5 g, 0.0625 mol) in THF (20 mL) was added MeI (2.9 g) dropwise at room temperature. The reaction mixture was stirred at room temperature for 1 hour, then added dropwise into water. The solids were precipitated out dissolved in ethyl acetate and purified by column chromatography on silica gel to give 12G (2.4 g, 40.7% yield).

후처리

  1. customThe solids were precipitated
  2. dissolutionout dissolved in ethyl acetate
  3. custompurified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-f436c9b2248b4f75b8fb50f49763a398
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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