Methanol → HCID 86722258, 화합물

HRID 869412노트

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HRID 869412 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][CH:22]=[C:23]([CH:25]=O)[N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].CO>O>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:25][C:23]1[N:24]=[C:20]([CH:17]([CH3:19])[CH3:18])[S:21][CH:22]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 27631922-(Propan-2-yl)-1,3-thiazole-4-carbaldehydeHCID 86722252HCID 86722252, 화합물

생성물 1

HCID 86722258HCID 86722258, 화합물수율 94.9%

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

A mixture of 12G (2 g, 7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (2.2 g, 14.6 mmol), NaOH (1.5 g) and MeOH (20 mL) was heated to 50° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15A (2.8 g, 94.4% yield).

후처리

  1. customreacted overnight
  2. customthe reaction
  3. filtrationThe precipitated solids were collected by filtration

출처 및 근거

ORD 기록
ord-c95180d3aade4f86bd59966307b6144b
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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