2-cyclopropyl-1H-1,3-benzodiazole → HCID 86721335, 화합물

HRID 869506

반응식

HRID 869506 반응식
[CH:1]1([C:4]2[NH:8][C:7]3[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=3[N:5]=2)[CH2:3][CH2:2]1.Br[CH2:14][C:15]1[CH:34]=[CH:33][C:18]2/[C:19](=[C:29](/[CH3:32])\[C:30]#[N:31])/[C:20]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=3[O:22][CH2:23][C:17]=2[CH:16]=1>>[CH:1]1([C:4]2[N:5]([CH2:14][C:15]3[CH:34]=[CH:33][C:18]4/[C:19](=[C:29](/[CH3:32])\[C:30]#[N:31])/[C:20]5[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=5[O:22][CH2:23][C:17]=4[CH:16]=3)[C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 10844192-cyclopropyl-1H-1,3-benzodiazoleHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

생성물 1

HCID 86721335HCID 86721335, 화합물수율 96.3%

실험 절차

Using 2-cyclopropyl-1H-benzo[d]imidazole (Europeane Journal of Organic Chemistry, 2000, p 1229, 69 mg, 0.434 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (160 mg, 0.447 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (182 mg, 95%) was obtained.

후처리

  1. customobtained in Reference Example 1

출처 및 근거

ORD 기록
ord-5adbb5e158554deb9cb74299d2350cb2
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969345B2

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