Methyl iodide → 3-Bromo-2-methoxy-5-methylpyridine
반응식
[Br:1][C:2]1[C:3]([OH:9])=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.I[CH3:11]>ClCCl.C(=O)([O-])[O-].[Ag+2]>[Br:1][C:2]1[C:3]([O:9][CH3:11])=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1참가 물질
5
실험 절차
To 3-bromo-5-methylpyridin-2-ol (500 mg, 2.7 mmol) and silver carbonate (2.6 g, 9.6 mmol) suspended in dichloromethane (10 mL) was added iodomethane (0.83 mL, 13 mmol). The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was filtered through a pad of celite and the volatiles were evaporated to yield 3-bromo-2-methoxy-5-methylpyridine, which was used directly in the next step. ESI-MS m/z calc. 201.0. found 202.3 (M+1)+. Retention time 1.51 minutes.
후처리
- filtrationThe reaction mixture was filtered through a pad of celite
- customthe volatiles were evaporated
출처 및 근거
- ORD 기록
- ord-87d2fd7b94f141d89814918cb66633fe
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969386B2
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