Sodium Hydroxide → Sodium 5-(4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}phenyl)tetrazol-2-ide

HRID 870064노트

반응식

HRID 870064 반응식
[CH3:1][C:2]1[S:3][C:4]([CH3:35])=[C:5]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[C:6]=1[C:7]([NH:9][C:10]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:20]=[N:21][NH:22][N:23]=3)=[CH:15][CH:14]=2)[CH2:12][CH2:11]1)=[O:8].[OH-].[Na+:37]>CCO>[CH3:1][C:2]1[S:3][C:4]([CH3:35])=[C:5]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=2)[C:6]=1[C:7]([NH:9][C:10]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:20]=[N:21][N-:22][N:23]=3)=[CH:15][CH:14]=2)[CH2:11][CH2:12]1)=[O:8].[Na+:37]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 249529282,5-Dimethyl-N-{1-[4-(2H-tetrazol-5-yl)phenyl]cyclopropyl}-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxamide

생성물 1

HCID 24953973Sodium 5-(4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}phenyl)tetrazol-2-ide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 2,5-dimethyl-N-{1-[4-(2H-tetrazol-5-yl)phenyl]cyclopropyl}-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxamide from Example 14, Step 3 (150 mg, 0.301 mmol) in EtOH (3 mL), was treated with NaOH (1.0N in water, 301 μL, 0.301 mmol). The solution then obtained was concentrated to dryness. Water (20 mL) was added to the residue. The turbid solution was frozen in a bath of dry ice and acetone and lyophilized to afford the desired product as an off-white fluffy solid. MS (−APCI): m/z 496 (M−23)−.

후처리

  1. customThe solution then obtained
  2. concentrationwas concentrated to dryness
  3. additionWater (20 mL) was added to the residue
  4. temperatureThe turbid solution was frozen in a bath of dry ice and acetone

출처 및 근거

ORD 기록
ord-4e69e387c7b644fc8251835c1433bd72
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969394B2

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