Hydrochloric Acid → 806595-48-2

HRID 870572

반응식

HRID 870572 반응식
Cl.[CH3:2][O:3][C:4](=[O:11])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]#[N:10].[CH2:12]([O:14]CC)C>CO>[NH:10]=[C:9]([O:14][CH3:12])[CH2:8][CH2:7][CH2:6][CH2:5][C:4]([O:3][CH3:2])=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2회HCID 554130Methyl 5-cyanopentanoate

생성물 1

HCID 23189824806595-48-2수율 83%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Bubble hydrogen chloride (g) through a 0° C. solution of 5-cyano-pentanoic acid methyl ester (3.0 mL; 1.00 equiv; 22.02 mmoles) in methanol (5 mL), and ethyl ether (10 mL) for 1 hour. Allow the solution to warm to room temperature then add 50 mL ethyl ether, stir vigorously for 15 minutes, then filter and collect the resulting precipitate. Wash the solid with ethyl ether to afford methyl 6-imino-6-methoxy-hexanoate (3.82 g; 83%): 1H NMR (DMSO) δ 1.47-1.62 (m, 4H), 2.31 (t, 2H), 2.59 (t, 2H), 3.56 (s, 3H), 4.03 (s, 3H).

후처리

  1. filtrationfilter
  2. customcollect the resulting precipitate
  3. washWash the solid with ethyl ether

출처 및 근거

ORD 기록
ord-c98fa7a79c2c40388b3ab71576959e67
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969555B2

연결된 노트

불러오는 중…