Sodium hydride → HCID 86696429, 화합물
반응식
Br[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[N:12]2[N:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]2=[N:10][CH:9]=1)=[O:6].[H-].[Na+]>CN(C=O)C.CCOC(C)=O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]2[N:12]([C:8]([N:7]3[CH2:2][CH2:3][CH2:4][C:5]3=[O:6])=[CH:9][N:10]=2)[N:13]=1참가 물질
5
실험 절차
To 1.0 g of 4-bromo-N-(6-chloroimidazo[1,2-b]pyridazin-3-yl)butanamide (3.15 mmol) dissolved in 39 mL DMF was added NaH (189 mg, 4.72 mmol), and stirred at rt for 0.5 hr. Dilute with 50 mL EtOAc and separate the organic layer. Wash twice with water, once with brine and dry over MgSO4. Concentrate to obtain the product 0.49 g (66%). No purification was needed.
후처리
- customseparate the organic layer
- washWash twice with water, once with brine
- dry with materialdry over MgSO4
- concentrationConcentrate
출처 및 근거
- ORD 기록
- ord-ef82852c93bb478197d76aa645b46d71
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969565B2
반응 노트
불러오는 중…