Water → 4-(4-Nitroisothiazol-5-yl)morpholine

HRID 871042노트

반응식

HRID 871042 반응식
Br[C:2]1[S:6][N:5]=[CH:4][C:3]=1[N+:7]([O-:9])=[O:8].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.CCN(C(C)C)C(C)C.O>O1CCOCC1>[N+:7]([C:3]1[CH:4]=[N:5][S:6][C:2]=1[N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)([O-:9])=[O:8]

참가 물질

6

반응물 4

HCID 962WaterHCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 126311735-Bromo-4-nitroisothiazole

생성물 1

HCID 712617854-(4-Nitroisothiazol-5-yl)morpholine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 5-bromo-4-nitroisothiazole (P) (500 mg, 2.39 mmol) and morpholine (6B2) (620 mg, 7.12 mmol) in dioxane (10 mL) at room temperature (25° C.) was added DIEA (851 μL, 4.78 mmol). The solution was stirred for 30 min and HPLC showed the reaction was complete. Water (10 mL) was then added. A precipitate was formed, filtered and air dried at room temperature to get the product 6C6 (500 mg, 2.32 mmol).

후처리

  1. customA precipitate was formed
  2. filtrationfiltered
  3. customair dried at room temperature
  4. customto get the product 6C6 (500 mg, 2.32 mmol)

출처 및 근거

ORD 기록
ord-1222045766594109a02eccc1ca989843
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969584B2

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