2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate

HRID 871044

반응식

HRID 871044 반응식
FC1C=CC=C(F)C=1C1SC=C(C(O)=O)N=1.[N:17]1[CH:22]=[CH:21][C:20]([C:23]2[S:24][CH:25]=[C:26]([C:28]([OH:30])=O)[N:27]=2)=[CH:19][CH:18]=1.[NH2:31][C:32]1[CH:33]=[N:34][S:35][C:36]=1[N:37]1[CH2:42][CH2:41][N:40]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[CH2:39][CH2:38]1>>[N:17]1[CH:18]=[CH:19][C:20]([C:23]2[S:24][CH:25]=[C:26]([C:28]([NH:31][C:32]3[CH:33]=[N:34][S:35][C:36]=3[N:37]3[CH2:38][CH2:39][N:40]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[CH2:41][CH2:42]3)=[O:30])[N:27]=2)=[CH:21][CH:22]=1

참가 물질

4

반응물 3

HCID 7160912-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acidHCID 242784542-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acidHCID 86720862Tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate

생성물 1

HCID 86720861Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate수율 89.3%

실험 절차

Following the procedure described in Step (3) of Example 6, and substituting Compounds 2E and 6D8 with 2-(pyridin-4-yl)thiazole-4-carboxylic acid (19E) (58 mg, 0.28 mmol) and tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate (31D3) (80 mg, 0.28 mmol) respectively, Compound 31A (120 mg, 0.25 mmol) was obtained.

출처 및 근거

ORD 기록
ord-74bcf30c1b6648f49792e395565db9c8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969584B2

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