Phosphorus oxychloride → 4-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline

반응식

[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2O.O=P(Cl)(Cl)[Cl:21]>>[Cl:21][C:9]1[C:8]2[C:13](=[CH:14][C:15]([O:16][CH3:17])=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[CH:7]=2)[N:12]=[CH:11][N:10]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 1784868706-(3-chloropropoxy)-7-methoxy-1H-quinazolin-4-one

생성물 1

HCID 507422644-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline수율 86%

실험 절차

The intermediate 6-(3-chloropropoxy)-4-hydroxy-7-methoxyquinazoline (3.5 g, 13.0 mmol) was reacted with POCl3 in the manner described in Example 4A Step 2 to give 4-chloro-6-(3-chloropropoxy)-7-methoxyquinazoline (3.2 g, 11.2 mmol, 86%). LC-MS (ESI) m/z 287 (M+H)+.

출처 및 근거

ORD 기록: ord-a3f9f61daf7b44e4b27b8a57c6c78af3
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08969587B2

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