Risedronate → Phosphate

HRID 871802

반응식

HRID 871802 반응식
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[OH-].[Na+].C1C=NC=C(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1>O>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([OH:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19]

참가 물질

6

반응물 3

HCID 5245RisedronateHCID 14798Sodium HydroxideHCID 131732542HCID 131732542, 화합물

생성물 2

HCID 1061PhosphateHCID 5245Risedronate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The risedronate-calcium-phosphate solution and 0.5N sodium hydroxide were simultaneously added to 100 mL water to maintain the pH at 7.00 until all the risedronate had been added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 105° C. 3.93 g of calcium complex salt of Risedronate with phosphate were thus obtained.

후처리

  1. additionhad been added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customThe solid was dried in an oven at 105° C

출처 및 근거

ORD 기록
ord-0a522a8974974305a5371efb11cab55e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08974801B2

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