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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → 7-Amino-8-(3-aminopropyl)-2-(4-morpholin-4-ylphenylamino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

HRID 871864
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인쇄 미리보기

반응식

HRID 871864 반응식
[NH2:1][C:2]1[N:24]([CH2:25][CH2:26][CH2:27][NH:28]C(=O)OC(C)(C)C)[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:14][CH:13]=3)[N:9]=[CH:10][C:5]=2[C:4](=[O:36])[C:3]=1[C:37](=[O:39])[NH2:38].[ClH:40].CCOCC>O1CCOCC1>[ClH:40].[NH2:1][C:2]1[N:24]([CH2:25][CH2:26][CH2:27][NH2:28])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([N:18]4[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)=[CH:16][CH:17]=3)[N:9]=[CH:10][C:5]=2[C:4](=[O:36])[C:3]=1[C:37]([NH2:38])=[O:39]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 67325689tert-Butyl {3-[7-amino-6-carbamoyl-2-(4-morpholin-4-ylphenylamino)-5-oxo-5H-pyrido[2,3-d]pyrimidin-8-yl]propyl}carbamate

생성물 1

HCID 709263867-Amino-8-(3-aminopropyl)-2-(4-morpholin-4-ylphenylamino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

시약·촉매·용매 1

HCID 31275
1,4-Dioxane
용매
2회

실험 절차

0.16 g (0.30 mmol) of the product prepared in step 11.4 is suspended in 4 mL of anhydrous dioxane, and 0.74 mL (2.95 mmol) of a 4N solution of hydrogen chloride in dioxane is added. The mixture is stirred at room temperature for 5 hours, and ether is added. The solid is drained by suction, rinsed with pentane and dried in an oven. 0.14 g of the expected product is obtained in the form of a white powder. Yield (dihydrochloride)=quantitative. m.p.=250°C. M+H+=439.

후처리

  1. washrinsed with pentane
  2. customdried in an oven

출처 및 근거

ORD 기록
ord-b8c109b6088e495e8b6aafb7ebb45a80
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08975250B2

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