Sodium Hydroxide → HCID 28806058, 화합물

HRID 872785노트

반응식

HRID 872785 반응식
[CH:1]([C:4]1[N:8]=[C:7]([C:9]([O:11]CC)=[O:10])[O:6][N:5]=1)([CH3:3])[CH3:2].O[NH:15]/[C:16](=N/[H])/[C:17]1C=CC=NC=1.[OH-].[Na+]>>[N:15]1[CH:16]=[CH:17][CH:2]=[C:1]([C:4]2[N:8]=[C:7]([C:9]([OH:11])=[O:10])[O:6][N:5]=2)[CH:3]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 534046373-Isopropyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl esterHCID 178506505HCID 178506505, 화합물

생성물 1

HCID 28806058HCID 28806058, 화합물

실험 절차

Following the procedure described in U.S. Pat. No. 5,578,550 for the preparation of ethyl 3-isopropyl-1,2,4-oxadiazole-5-carboxylate, the title product was prepared from (E)—N-hydroxynicotinimidamide (2.727 g, 19.88 mmol) and ethyl oxalyl chloride (2.89 mL, 25.9 mmol) followed by subsequent ester hydrolysis with sodium hydroxide solution according to Example 225(b). Yield 1.32 g. 1H NMR (400 MHz; d6-DMSO): δ 7.63 (m, HA), 8.32 (m, 1H), 8.86 (dd, 1H), 9.03 (dd, 1H).

출처 및 근거

ORD 기록
ord-4e8d11574bb147d5890808d17f26ad31
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975254B2

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