1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 178461741, 화합물

HRID 872792노트

반응식

HRID 872792 반응식
[NH2:1][C@@H:2]([CH3:19])[CH2:3][N:4]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([Cl:17])[C:10]=2[F:18])=[N:5]1.[NH:20]1[CH:24]=[C:23]([C:25]2[S:26][CH:27]=[C:28]([C:30](O)=[O:31])[N:29]=2)[N:22]=[CH:21]1.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C>CN(C=O)C>[Cl:17][C:11]1[C:10]([F:18])=[C:9]([C:6]2[CH:7]=[CH:8][N:4]([CH2:3][C@@H:2]([NH:1][C:30]([C:28]3[N:29]=[C:25]([C:23]4[N:22]=[CH:21][NH:20][CH:24]=4)[S:26][CH:27]=3)=[O:31])[CH3:19])[N:5]=2)[CH:16]=[CH:15][C:12]=1[C:13]#[N:14]

참가 물질

7

반응물 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 67172691HCID 67172691, 화합물HCID 178524836HCID 178524836, 화합물

생성물 1

HCID 178461741HCID 178461741, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared from (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-3-fluorobenzonitrile (0.3 g, 1.07 mmol), 2-(1H-imidazol-4-yl)thiazole-4-carboxylic acid (0.25 g, 1.29 mmol), HOBt (0.22 g, 1.61 mmol), DIPEA (0.56 mL, 3.23 mmol) and EDCI (0.31 g, 1.61 mmol) in 10 mL DMF as solvent using the method described in Example 34(d). Yield 65 mg. 1H NMR (400 MHz; CDCl3): δ 1.27 (d, 3H), 4.40 (m, 2H), 4.60 (m, 1H), 6.80 (dd, 1H), 7.24 (d, 1H), 7.30 (m, 1H), 7.56 (m, 2H), 7.70 (d, 1H), 8.02 (s, 1H), 8.08 (m, 1H).

출처 및 근거

ORD 기록
ord-e8849522e56340a094c69a2b7ffab4ca
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975254B2

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