Hydrochloric Acid → cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile

HRID 873035노트

반응식

HRID 873035 반응식
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH:4]2[C:8]3[CH:9]=[C:10]([C:15]#[N:16])[CH:11]=[CH:12][C:13]=3[CH2:14][CH:3]12.C([C@](C(O)=O)(O)[C@](C(=O)C1C=CC=CC=1)(O)C(O)=O)(=O)C1C=CC=CC=1>>[NH:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]2[C:8]3[CH:9]=[C:10]([C:15]#[N:16])[CH:11]=[CH:12][C:13]=3[CH2:14][C@H:3]12

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 12362977Di-benzoyl-d-tartaric acidHCID 671950702,3,4,4a,9,9a-Hexahydro-1H-indeno(2,1-b)pyridine-6-carbonitrile

생성물 1

HCID 67224019cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile

실험 절차

reacting the HCl salt of 2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile with base followed by di-benzoyl-d-tartaric acid to provide (4aR,9aS)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile.½ D-DTBA:

출처 및 근거

ORD 기록
ord-a3c8dd90e0874017988588273485db3f
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975405B2

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