Potassium tert-butoxide → 1H-Indazole

HRID 873695

반응식

HRID 873695 반응식
C([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)C1C=CC=CC=1.CC(C)([O-])C.[K+]>CS(C)=O>[NH:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=[N:9]1

참가 물질

4

반응물 2

HCID 23665647Potassium tert-butoxideHCID 178420212HCID 178420212, 화합물

생성물 1

HCID 92211H-Indazole

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Benzyl-indazole is dissolved in dimethylsulfoxide and potassium tert-butoxide (1 M solution in tetrahydrofuran) is added at room temperature. Oxygen is then bubbled into the solution for 5 minutes. The reaction is allowed to stir at room temperature for 18 h. The reaction is quenched with aqueous saturated ammonium chloride then extracted three times with ethyl acetate. The combined organic extracts are dried over sodium sulfate, and concentrated. Purification by flash chromatography provides the deprotected indazole.

후처리

  1. customOxygen is then bubbled into the solution for 5 minutes
  2. customThe reaction is quenched with aqueous saturated ammonium chloride
  3. extractionthen extracted three times with ethyl acetate
  4. dry with materialThe combined organic extracts are dried over sodium sulfate
  5. concentrationconcentrated
  6. customPurification by flash chromatography

출처 및 근거

ORD 기록
ord-6cb6da7bd79d4de8af7ec6f460070b6a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975439B2

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