N-Iodosuccinimide → ethyl 4-iodo-5-methyl-1H-pyrazole-3-carboxylate
반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[NH:4][N:3]=1.C1C(=O)N([I:19])C(=O)C1>CN(C=O)C>[I:19][C:6]1[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][NH:3][C:2]=1[CH3:1]참가 물질
4
실험 절차
To a stirred solution of ethyl 3-methylpyrazole-5-carboxylate (3.11 g, 20.17 mmol) in DMF (50 mL) under Ar at 0° C. was added NIS (5.90 g, 26.2 mmol). The reaction mixture was stirred 20 hr at rt and quenched with 500 mL of water. The resulting precipitate was collected to afford the title product (5.61 g, 20.03 mmol, 99% yield) as a white solid. tR: 3.75 min (HPLC 1); tR: 0.78 min (LC-MS 2); ESI-MS: 281 [M+H]+ (LC-MS 2)
후처리
- customquenched with 500 mL of water
- customThe resulting precipitate was collected
출처 및 근거
- ORD 기록
- ord-f10b5e2764a14411aa8d29ad518682e2
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08975417B2
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