N-bromobutanimide → HCID 67125220, 화합물

HRID 874184노트

반응식

HRID 874184 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][N:11]=[C:10]([CH3:19])[N:9]=1.[Br:20]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:20][CH2:19][C:10]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][N:11]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 18981952Ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate

생성물 1

HCID 67125220HCID 67125220, 화합물

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

820 mg (2.96 mmol) of ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate and 633 mg (3.55 mmol) of N-bromosuccinimide were dissolved in 18 ml of carbon tetrachloride and, with stirring, heated to the boil. At boiling point, 49 mg (0.29 mmol) of 2,2′-azobis-2-methylpropionitrile were added a little at a time over a period of 5 hours, followed by refluxing for a further hour. After cooling to room temperature, the reaction solution was filtered and the mother liquor was freed from the solvent under reduced pressure. The desired product was isolated by chromatographic purification.

후처리

  1. temperatureheated to the boil
  2. additionwere added a little at a time over a period of 5 hours
  3. temperatureby refluxing for a further hour
  4. filtrationthe reaction solution was filtered

출처 및 근거

ORD 기록
ord-f560c7d869f14d1fb147ae7209bc58bf
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980886B2

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